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KMID : 0928320070070040238
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Korean Journal of Health Promotion and Disease Prevention
2007 Volume.7 No. 4 p.238 ~ p.244
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Relationship between Bone Mineral Density and Blood Lipid in Young and Middle-Aged Men and Pre-Menopausal Women
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Suh Young-Sung
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Abstract
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Background: Although some cross sectional studies found association between lipid profile and bone mineral density(BMD) in human, neither large population-based studies nor prospective studies support links between lipid levels and BMD. The aim of this study was to investigate association of lipid level and BMD after adjustment for obesity in Korean.
Methods: 180 adult subjects enrolled from health promotion center and Obesity Clinic at university hospital. 80 male subjects were lower than 50 year-old. 100 female subject were pre-menopausal women. Anthropometric data and lipid profile were determined. BMD of whole body was measured by dual energy X-ray absorptiometry.
Results: 1. Partial correlations analysis between bone mineral content, BMD at various sites and lipid profile were performed. Lipid profile in male was inversely related with various sites of BMD and bone mineral content. In female subjects, HDL cholesterol and triglyceride were negatively and positively associated with various sites of BMD and bone mineral content. 2. In subgroup analysis according to blood level of lipid, higher level group of total cholesterol was significantly lower bone mineral content, total BMD, head BMD, and spine BMD in male subjects. Higher level group of HDL cholesterol was significantly lower bone mineral content, total BMD, and spine BMD. In female subjects, bone mineral content was significantly different between subgroup of total cholesterol and HDL cholesterol.
Conclusions: This study suggest that lipid profile may be inversely associated with BMD in male subjects, and HDL cholesterol and triglyceride may be related with BMD in female subjects.
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KEYWORD
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lipid profile, bone mineral density, osteoporosis
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